K9 Advantix II is better than Seresto if you want to choose between two. K9 Advantix II comes in all sizes of dogs and has better protection against fleas, ticks, and mosquitoes than Seresto.

Best Choice: K9 Advantix II

K9 Advantix II comes for dogs of every size from Small (weighing 4-10 lbs), Medium (11-20 lbs), Large (21-55 lbs), and Extra Large (over 55 lbs).

K9 Advantix II comes in pre-measured and single-use pipettes that are simple to apply to your dog’s skin. You need to part the fur behind your dog’s shoulder blades and pour the pipette’s contents on your pet’s skin. Do not try to rub the liquid into your dog’s hair, and do not touch them until the solution has been completely absorbed and dried.

K9 Advantix II kills fleas and ticks effectively, but it also kills biting flies and mosquitoes. It kills the mosquitoes that can spread Dirofilaria immitis, which causes Dirofilariasis/heartworm infection in animals and sometimes in humans.

One significant difference between Seresto and K9 Advantix II is that this topical treatment contains a greater number of active ingredients. Imidacloprid (8.8%), Permethrin (44%), and Pyriproxyfen (0.44%) are present in this product. Imidacloprid effectively kills both larval and adult fleas. Pyriproxyfen stops insect growth and prevents the development of flea larvae and eggs from going to the next level. Permethrin kills mosquitoes and ticks while still repelling them.

These active ingredients target pests’ nervous systems by interfering with nerve signaling. These parasites become paralyzed and eventually die as a result of this.

K9 Advantix II stays intact in your dog’s body for around 4 weeks after application. However, those pets having serious flea infections may need to repeat the treatment within the period of 4 weeks. If you think it’s appropriate, you need to consult your veterinarian before using this product over the 4-week timeframe to avoid side effects or overuse. Always remember that K9 Advantix II can’t be used twice a week.

You should also know that fleas crawl up your dog’s hair when they feel the impact of the ingredients. In this case, you might think that the product isn’t working as you notice more fleas after its use, but this is not true. In fact, if you see fleas after its use, then the product is definitely working.

If you see ticks attached to your dog during the application, you should immediately remove them with a suitable tool since they are not destroyed right away and can spread disease. This product will repel fleas in 3 days and kill the fleas present on your dog in 12 hours.

K9 Advantix II is best as it sits on the dog’s skin and does not let the solution get into their bloodstream. It easily kills parasites of all life stages, whether they are eggs or fully grown hiding in your dog’s thick coat.

They are odorless, non-greasy, and come in a liquid form that is easy to apply. It can be used on dogs of all types of fur and all sizes. It also saves your dog from having any skin issues, lethargy, and neurological problems.

It is sunlight resistant and waterproof and could only come off with dog shampoo. Dogs love when they could freely swim in the water without having to tie anything around their neck.

You are free to choose what amount of the product is sufficient for your dog, unlike other products.

Pros

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Waterproof

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Suitable for 8 weeks old puppies

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Can prevent the spread of heartworm disease/Dirofilariasis

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Fleas, mosquitoes, ticks, and biting flies are all repelled

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Fleas can be killed in 12 hours

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Disturbs the flea life cycle

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The formula is resistant to both water and sunlight

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Since dogs like it, there will be no biting

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Odourless and dries in 2-3 hours

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It’s gentle on the dog’s body and has fewer side effects

Cons

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Toxic to cats

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Heavily infected dogs may require a second treatment

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Can burn smaller dogs’ skin

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Expensive than other topical flea solutions

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Dog may become drowsy after its application

Seresto Flea and Tick Collar

Seresto collar is a simple plastic collar that is wrapped around your dog’s neck like a control collar, and you can trim away any excess. To guarantee a good fit, you can simply place two fingers beneath the collar. You need to check this collar in a similar manner on a daily basis to make sure it fits comfortably. If your dog is still evolving, this is extremely crucial.

Seresto is approved for use on dogs and cats to remove fleas and ticks. The collar also comes in handy to cure sarcoptic mange and lice infestations, as well as to keep your dog safe from sandflies, which can spread the disease Leishmaniosis.

Seresto dog collars contain two standard active ingredients: 4.5% Flumethrin and 10% Imidacloprid. Adult fleas and flea larvae are killed by Imidacloprid, while ticks and their larvae are killed by Flumethrin. Seresto collars use patented “Bayer Polymer Matrix” technology to unleash active ingredients in a regulated manner for an 8-month period.

These ingredients are then dispersed across the skin and fur of your dog. Ticks do not have to bite your dog to be repelled; just getting the ticks into touch with the ingredients in their hair is enough. These active ingredients are then ingested into the parasite’s body, where they bind to their nervous system receptors, disrupting nerve contact. It causes the bug to become paralyzed and eventually die.

Seresto collars are safe for most dogs for up to 8 months. The active ingredients in the collar begin to release continuously once the package is opened. So, it is advised to open it whenever you’re ready to tie the collar on your dog.

Fleas and their larvae are effectively killed in 24 hours, and although ticks might require up to 48 hours to die, one study found that the collar had some tick-killing activity within 6 hours of use.

Seresto collars are great as they are odorless, non-greasy, and simple to tie and remove. You don’t need to wait for hours for the product to fully absorb or dry in their skin. It is great as you don’t have to worry about getting your furniture or clothes stained.

The excessive collar can be easily chopped off. Although the collar is water-resistant, it is best to remove it before giving your dog a bath or swimming as it could mess with its effectiveness.

Seresto Collar also works for dogs with all coat types, so if your dog has thick fur, it will still be completely covered by this product. It is hassle-free as you don’t have to think about reapplying the treatment every month like other products.

It is best for dogs, cats and safe for humans. It also releases the product in a safe quantity with fewer side effects. However, in some cases, it causes itching, hair loss, dermatitis, redness, and neurological signs in dogs.

Pros

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Non-greasy and odorless

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Simple to use

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Easy to remove if cause any side effects

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It lasts up to 6 to 8 months

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Flea repellent

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Kills more than ticks and fleas

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Kills on touch

Cons

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Very expensive as compared to K9 Advantix II

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Can cause side effects to some dogs

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When humans come into contact with the collar, they can develop skin sensitivities

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Water could make this product less effective

Final  Verdict

K9 Advantix II is highly effective in repelling and killing not only ticks and fleas but also prevents your dog from getting diseases from mosquitoes called Dirofilaria immitis/Heartworm. It is best for dogs over 4 pounds and lasts up to 4 weeks. It is also safe to use this product on pregnant, lactating, or breeding dogs. The active ingredients present in this topical flea treatment kill the parasites in 12 hours. It is best for dogs who love to swim as it is water-resistant and only comes off using dog shampoo.

Seresto Collar is competing great with its ability to kill fleas and ticks as well as protection against sarcoptic mange and lice. However, it can also cause itching, hair loss, dermatitis, redness, and neurological signs in some dogs. It is also quite expensive as compared to K9 Advantix II. It has active ingredients that kill parasites within 24 hours. It is a good choice if you’re looking for a product to work for 8 months.